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Afc may refer to:
The AFC is the Asian Football Confederation, the governing body for association football in Asia.
AFC was one of the two major conferences in the NFL from 1970 until the 1990s, before being retained as the AFC division for playoffs.
AFC can refer to an Air Force component/command in military contexts, used in various national defense structures.
AFC is used as an acronym for certain documented admissions-fraud legal matters in the U.S., depending on the case caption.