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Centaurus may refer to:
A prominent southern constellation named after the centaur from Greek mythology.
A nearby radio galaxy in the constellation Centaurus, one of the most studied active galaxies.
An X-ray binary/nebula region in the constellation Centaurus, associated with a stellar system often referred to in high-energy astronomy.
A common shorthand for stars in the Centaurus region, most notably Alpha Centauri (the nearest star system to the Sun).