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Disease Outbreak may refer to:
A global outbreak of coronavirus disease 2019 caused by SARS‑CoV‑2, declared a pandemic in 2020.
A major Ebola outbreak in West Africa (notably Guinea, Liberia, and Sierra Leone) that began in 2014 and peaked in 2015.
A worldwide influenza outbreak in 1918–1919 that infected an estimated one-third of the global population.
An outbreak of severe acute respiratory syndrome (SARS) that spread globally from 2002 to 2004.